Men In Black 3 is Will Smith’s first film in 3.5 years, since the release of Seven Pounds in December 2008.
Comic actor Sacha Baron Cohen was considered for the role of Boris.
Gemma Arterton was originally cast as young Agent O, but scheduling conflicts prevented Arterton from taking the role.
Men in Black II was released the same year as Spider-Man. This film, the sequel, releases ten years later; the same year as the new film The Amazing Spider-Man.
This is the second threequel Steven Spielberg produced that involves Apollo 11 in its storyline. The first was Transformers: Dark of the Moon which focused on a Transformer ship discovered by Apollo.